Yes, I think so.

I think these people are called high-functioning psychopaths in our society, which is a reflection of its all-pervasive fear. Most, of course, don’t come out for there’s no reason to. Those who do come out say interesting things.

Such people don’t experience “normal” human emotion, don’t connect to others emotionally, and they’re totally harmless. They also don’t fear death, because they have never lost the understanding that the experience of the present moment is all there is in life, so how can one fear what one will never experience? They cannot relate to people’s fear of death, and they view life as a game, just like an enlightened person would. For one reason or the other, they just don’t seem to have caught the “bug” (ego) when they were growing up.

They cannot relate to people’s misery and suffering, and consequently, to the very concept of enlightenment. The difference, though, is that they have never experienced this suffering, so they can only understand it to the degree that it’s explained to them. They had to learn how people are by observation, to be able to communicate and cooperate with them. So their understanding of human condition is very limited, very theoretical. People appear weird to them, but since they are in extreme minority, they are at peace with the idea that it is them who’s weird. And they don’t care - it’s not like someone can pick up human condition consciously, there’s no way back, you can only do it when you’re very little, in childhood.

A person who became enlightened actually lived in both worlds, so he knows human condition intimately. He also knows how he got out of it. He knows both, so there’s no question in his mind what’s real and what’s not, so even though he similarly views people as weird, no one can convince him that it is him that is not normal, because he remembers his own prior insanity and he knows his own current sanity. So he can teach based on his prior experience, as he would be teaching his old self, and a high-functioning psychopath cannot.

Otherwise there’s probably not a lot of difference. Maybe there’s some bodily conditioning with regards to what food they were taught to eat, but I don’t honestly think high-functioning psychopaths have much mental conditioning. I read an interview with one and I couldn’t see much difference.